ABSTRACT
The Sars-Cov2 pandemic has demonstrated the strong link between health risk and perception of the disease for various reasons: Because it is an event that is being faced for the first time and because the consequences of the disease are still completely unknown. The objective of the article is to give a voice to people who have experienced the disease. Following a qualitative approach, twenty in-depth interviews were conducted with people recovered from Sars- Cov2 living in southern Lazio, using the R-Text Mining Package software as an analysis tool. From the analysis of the interviews, conducted through text mining, word relationships and sentiment analysis, a series of particularly relevant areas and dimensions emerged in order to assess the impact that the disease has had on people's experiences, both on an individual and social level. Specifically, three main topics emerged: Communication, fear and danger. © 2021 Franco Angeli Edizioni. All rights reserved.
ABSTRACT
The Sars-Cov2 pandemic has demonstrated the strong link between health risk and perception of the disease for various reasons: Because it is an event that is being faced for the first time and because the consequences of the disease are still completely unknown. The objective of the article is to give a voice to people who have experienced the disease. Following a qualitative approach, twenty in-depth interviews were conducted with people recovered from Sars- Cov2 living in southern Lazio, using the R-Text Mining Package software as an analysis tool. From the analysis of the interviews, conducted through text mining, word relationships and sentiment analysis, a series of particularly relevant areas and dimensions emerged in order to assess the impact that the disease has had on people's experiences, both on an individual and social level. Specifically, three main topics emerged: Communication, fear and danger. © 2021 Franco Angeli Edizioni. All rights reserved.
ABSTRACT
Background and Aims: Recent studies have found that COVID-19 patients displayed resistance to fibrinolysis and that neutrophil extracellular traps (NETs) contributed to pulmonary microthrombotic complications of COVID-19.We aimed to analyze and compare AIS thrombi from COVID-19 and non COVID19 patients and to determine whether and how NETs played a role in their resistance to thrombolysis. Methods: A total of 32 thrombi, recovered from COVID-19 AIS patients (N=15) or non-COVID-19 patients (N=17) and treated with endovascular therapy, were analyzed by immunohistology, RT-PCR, or subjected to ex vivo thrombolysis. Results: All analyzed COVID-19 AIS thrombi were rich in neutrophils and NETs. SARS-CoV-2 RNA was not detected in the 3 COVID-19 positive analyzed thrombi. Ex vivo thrombolysis assay revealed a highly resistant pattern to tPA-induced thrombolysis in both groups. The addition of DNase 1 successfully reversed this thrombolysis resistance in a same proportion in both groups. Conclusions: Our results identify NETs as important mediators of fibrinolysis resistance in patients with AIS independently of the COVID-19. NETs-targeting therapy with DNase 1 could offer a therapeutic opportunity to improve the efficacy of tPA in all AIS population regardless of the underlying AIS etiology.